CA1152001A - Method for producing pertussis toxoid - Google Patents
Method for producing pertussis toxoidInfo
- Publication number
- CA1152001A CA1152001A CA000368112A CA368112A CA1152001A CA 1152001 A CA1152001 A CA 1152001A CA 000368112 A CA000368112 A CA 000368112A CA 368112 A CA368112 A CA 368112A CA 1152001 A CA1152001 A CA 1152001A
- Authority
- CA
- Canada
- Prior art keywords
- fluid
- pertussis
- toxoid
- amino acid
- formalin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 201000005702 Pertussis Diseases 0.000 title claims abstract description 36
- 238000004519 manufacturing process Methods 0.000 title description 5
- 239000012530 fluid Substances 0.000 claims abstract description 46
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 claims abstract description 45
- 231100000776 exotoxin Toxicity 0.000 claims abstract description 18
- 239000002095 exotoxin Substances 0.000 claims abstract description 18
- OTLLEIBWKHEHGU-UHFFFAOYSA-N 2-[5-[[5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy]-3,4-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-3,5-dihydroxy-4-phosphonooxyhexanedioic acid Chemical compound C1=NC=2C(N)=NC=NC=2N1C(C(C1O)O)OC1COC1C(CO)OC(OC(C(O)C(OP(O)(O)=O)C(O)C(O)=O)C(O)=O)C(O)C1O OTLLEIBWKHEHGU-UHFFFAOYSA-N 0.000 claims abstract description 17
- 150000001413 amino acids Chemical class 0.000 claims abstract description 12
- 239000012141 concentrate Substances 0.000 claims abstract description 12
- 241000588832 Bordetella pertussis Species 0.000 claims abstract description 9
- 239000002158 endotoxin Substances 0.000 claims abstract description 9
- 239000012228 culture supernatant Substances 0.000 claims abstract description 7
- 230000003311 flocculating effect Effects 0.000 claims abstract description 5
- 238000000034 method Methods 0.000 claims description 25
- 239000000203 mixture Substances 0.000 claims description 13
- 229930006000 Sucrose Natural products 0.000 claims description 7
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims description 7
- 238000000502 dialysis Methods 0.000 claims description 7
- 239000005720 sucrose Substances 0.000 claims description 7
- 239000000725 suspension Substances 0.000 claims description 7
- 238000010790 dilution Methods 0.000 claims description 6
- 239000012895 dilution Substances 0.000 claims description 6
- BFNBIHQBYMNNAN-UHFFFAOYSA-N ammonium sulfate Chemical compound N.N.OS(O)(=O)=O BFNBIHQBYMNNAN-UHFFFAOYSA-N 0.000 claims description 5
- 229910052921 ammonium sulfate Inorganic materials 0.000 claims description 5
- 235000011130 ammonium sulphate Nutrition 0.000 claims description 5
- 238000005189 flocculation Methods 0.000 claims description 2
- 230000016615 flocculation Effects 0.000 claims description 2
- 238000011534 incubation Methods 0.000 claims description 2
- 238000005185 salting out Methods 0.000 claims description 2
- 238000002525 ultrasonication Methods 0.000 claims description 2
- 230000003053 immunization Effects 0.000 abstract description 4
- 230000001988 toxicity Effects 0.000 abstract description 3
- 231100000419 toxicity Toxicity 0.000 abstract description 3
- 229960004279 formaldehyde Drugs 0.000 description 14
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 11
- 239000006228 supernatant Substances 0.000 description 10
- 229960005486 vaccine Drugs 0.000 description 10
- 230000036515 potency Effects 0.000 description 9
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 description 8
- 235000001014 amino acid Nutrition 0.000 description 8
- 229940024606 amino acid Drugs 0.000 description 8
- 239000002609 medium Substances 0.000 description 6
- 239000011780 sodium chloride Substances 0.000 description 6
- 235000002639 sodium chloride Nutrition 0.000 description 6
- 210000004027 cell Anatomy 0.000 description 5
- 235000019256 formaldehyde Nutrition 0.000 description 5
- 229940031418 trivalent vaccine Drugs 0.000 description 5
- NTYJJOPFIAHURM-UHFFFAOYSA-N Histamine Chemical compound NCCC1=CN=CN1 NTYJJOPFIAHURM-UHFFFAOYSA-N 0.000 description 4
- 235000019766 L-Lysine Nutrition 0.000 description 4
- 239000004472 Lysine Substances 0.000 description 4
- 206010013023 diphtheria Diseases 0.000 description 4
- 229960003983 diphtheria toxoid Drugs 0.000 description 4
- 208000015181 infectious disease Diseases 0.000 description 4
- 238000002156 mixing Methods 0.000 description 4
- 239000000243 solution Substances 0.000 description 4
- 229960000814 tetanus toxoid Drugs 0.000 description 4
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 3
- 241000283973 Oryctolagus cuniculus Species 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 206010043376 Tetanus Diseases 0.000 description 3
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 3
- 229910052782 aluminium Inorganic materials 0.000 description 3
- 238000005119 centrifugation Methods 0.000 description 3
- 238000000432 density-gradient centrifugation Methods 0.000 description 3
- 238000001784 detoxification Methods 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 230000003067 hemagglutinative effect Effects 0.000 description 3
- 206010024378 leukocytosis Diseases 0.000 description 3
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 3
- 239000013049 sediment Substances 0.000 description 3
- 229910052708 sodium Inorganic materials 0.000 description 3
- 239000011734 sodium Substances 0.000 description 3
- RTKIYNMVFMVABJ-UHFFFAOYSA-L thimerosal Chemical compound [Na+].CC[Hg]SC1=CC=CC=C1C([O-])=O RTKIYNMVFMVABJ-UHFFFAOYSA-L 0.000 description 3
- 229940033663 thimerosal Drugs 0.000 description 3
- 241000894006 Bacteria Species 0.000 description 2
- 208000035473 Communicable disease Diseases 0.000 description 2
- 108010010803 Gelatin Proteins 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- DFPAKSUCGFBDDF-UHFFFAOYSA-N Nicotinamide Chemical compound NC(=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-UHFFFAOYSA-N 0.000 description 2
- 206010037660 Pyrexia Diseases 0.000 description 2
- VSCWAEJMTAWNJL-UHFFFAOYSA-K aluminium trichloride Chemical compound Cl[Al](Cl)Cl VSCWAEJMTAWNJL-UHFFFAOYSA-K 0.000 description 2
- 230000037396 body weight Effects 0.000 description 2
- LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 2
- 238000001914 filtration Methods 0.000 description 2
- 239000008273 gelatin Substances 0.000 description 2
- 229920000159 gelatin Polymers 0.000 description 2
- 235000019322 gelatine Nutrition 0.000 description 2
- 235000011852 gelatine desserts Nutrition 0.000 description 2
- RWSXRVCMGQZWBV-WDSKDSINSA-N glutathione Chemical compound OC(=O)[C@@H](N)CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O RWSXRVCMGQZWBV-WDSKDSINSA-N 0.000 description 2
- 229960001340 histamine Drugs 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 239000012528 membrane Substances 0.000 description 2
- 239000008363 phosphate buffer Substances 0.000 description 2
- 239000002953 phosphate buffered saline Substances 0.000 description 2
- 239000002504 physiological saline solution Substances 0.000 description 2
- 229920000053 polysorbate 80 Polymers 0.000 description 2
- 239000002244 precipitate Substances 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 239000013587 production medium Substances 0.000 description 2
- 230000001737 promoting effect Effects 0.000 description 2
- 239000002510 pyrogen Substances 0.000 description 2
- 238000011218 seed culture Methods 0.000 description 2
- 230000001235 sensitizing effect Effects 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- QIJRTFXNRTXDIP-UHFFFAOYSA-N (1-carboxy-2-sulfanylethyl)azanium;chloride;hydrate Chemical compound O.Cl.SCC(N)C(O)=O QIJRTFXNRTXDIP-UHFFFAOYSA-N 0.000 description 1
- 229920001817 Agar Polymers 0.000 description 1
- 241000588807 Bordetella Species 0.000 description 1
- 241000283690 Bos taurus Species 0.000 description 1
- 241000237074 Centris Species 0.000 description 1
- 108010053187 Diphtheria Toxin Proteins 0.000 description 1
- 102000016607 Diphtheria Toxin Human genes 0.000 description 1
- 108010024636 Glutathione Proteins 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- 239000001888 Peptone Substances 0.000 description 1
- 108010080698 Peptones Proteins 0.000 description 1
- 108010081690 Pertussis Toxin Proteins 0.000 description 1
- 241001510071 Pyrrhocoridae Species 0.000 description 1
- 235000002595 Solanum tuberosum Nutrition 0.000 description 1
- 244000061456 Solanum tuberosum Species 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 1
- 239000007983 Tris buffer Substances 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 239000008272 agar Substances 0.000 description 1
- 235000010419 agar Nutrition 0.000 description 1
- 230000004523 agglutinating effect Effects 0.000 description 1
- 150000003863 ammonium salts Chemical class 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 230000027455 binding Effects 0.000 description 1
- 238000009739 binding Methods 0.000 description 1
- 238000004166 bioassay Methods 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 239000007465 bordet-gengou-medium Substances 0.000 description 1
- 239000000872 buffer Substances 0.000 description 1
- AIYUHDOJVYHVIT-UHFFFAOYSA-M caesium chloride Chemical compound [Cl-].[Cs+] AIYUHDOJVYHVIT-UHFFFAOYSA-M 0.000 description 1
- 230000010261 cell growth Effects 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 239000012531 culture fluid Substances 0.000 description 1
- 229960001305 cysteine hydrochloride Drugs 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 210000003743 erythrocyte Anatomy 0.000 description 1
- 238000000855 fermentation Methods 0.000 description 1
- 230000004151 fermentation Effects 0.000 description 1
- 238000002523 gelfiltration Methods 0.000 description 1
- 229960003180 glutathione Drugs 0.000 description 1
- 230000005484 gravity Effects 0.000 description 1
- 238000003306 harvesting Methods 0.000 description 1
- GPRLSGONYQIRFK-UHFFFAOYSA-N hydron Chemical compound [H+] GPRLSGONYQIRFK-UHFFFAOYSA-N 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 238000002649 immunization Methods 0.000 description 1
- 238000011081 inoculation Methods 0.000 description 1
- 229960003966 nicotinamide Drugs 0.000 description 1
- 235000005152 nicotinamide Nutrition 0.000 description 1
- 239000011570 nicotinamide Substances 0.000 description 1
- 235000019319 peptone Nutrition 0.000 description 1
- 229940066827 pertussis vaccine Drugs 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 238000006116 polymerization reaction Methods 0.000 description 1
- 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 description 1
- AVTYONGGKAJVTE-OLXYHTOASA-L potassium L-tartrate Chemical compound [K+].[K+].[O-]C(=O)[C@H](O)[C@@H](O)C([O-])=O AVTYONGGKAJVTE-OLXYHTOASA-L 0.000 description 1
- 239000001472 potassium tartrate Substances 0.000 description 1
- 229940111695 potassium tartrate Drugs 0.000 description 1
- 235000011005 potassium tartrates Nutrition 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 238000012552 review Methods 0.000 description 1
- 238000004062 sedimentation Methods 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
- 231100000765 toxin Toxicity 0.000 description 1
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P1/00—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes
- C12P1/04—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes by using bacteria
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
- C12N1/205—Bacterial isolates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K2039/10—Brucella; Bordetella, e.g. Bordetella pertussis; Not used, see subgroups
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/82—Proteins from microorganisms
- Y10S530/825—Bacteria
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Mycology (AREA)
- Medicinal Chemistry (AREA)
- Tropical Medicine & Parasitology (AREA)
- Virology (AREA)
- Biomedical Technology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP127825/1980 | 1980-09-12 | ||
| JP55127825A JPS5750925A (en) | 1980-09-12 | 1980-09-12 | Preparation of pertussis toxoid |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA1152001A true CA1152001A (en) | 1983-08-16 |
Family
ID=14969595
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA000368112A Expired CA1152001A (en) | 1980-09-12 | 1981-01-08 | Method for producing pertussis toxoid |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US4455297A (en]) |
| EP (1) | EP0047802B1 (en]) |
| JP (1) | JPS5750925A (en]) |
| KR (1) | KR840001512B1 (en]) |
| CA (1) | CA1152001A (en]) |
| DE (1) | DE3069433D1 (en]) |
| DK (1) | DK155915C (en]) |
| ES (1) | ES8202058A1 (en]) |
| GB (1) | GB2083358A (en]) |
| HU (1) | HU185404B (en]) |
| NO (1) | NO159667C (en]) |
| SU (1) | SU1297712A3 (en]) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS59206316A (ja) * | 1983-05-11 | 1984-11-22 | Kaken Pharmaceut Co Ltd | インシユリン分泌増強活性物質誘導体およびその製法 |
| US4551429A (en) * | 1983-09-15 | 1985-11-05 | American Home Products Corporation | Stimulation of antigen production by Bordetella pertussis |
| US4563303A (en) * | 1984-04-14 | 1986-01-07 | Judicial Foundation The Chemosero-Therapeutic Research Institute | Method for purification of filamentous hemagglutinin |
| GB8412207D0 (en) * | 1984-05-12 | 1984-06-20 | Wellcome Found | Antigenic preparations |
| JPS60155127A (ja) * | 1984-12-10 | 1985-08-15 | Teijin Ltd | 生物学的活性物質の製法 |
| GB8512972D0 (en) * | 1985-05-22 | 1985-06-26 | Univ Glasgow | Vaccine production |
| GB8601279D0 (en) * | 1986-01-20 | 1986-02-26 | Public Health Lab Service | Purification of pertussis antigens |
| FR2597344B1 (fr) * | 1986-04-16 | 1989-06-23 | Merieux Inst | Perfectionnement au procede de purification d'antigenes proteiques de bacteries appartenant au genre bordetella, en vue de l'obtention d'un vaccin acellulaire. |
| US4705686A (en) * | 1986-05-09 | 1987-11-10 | American Cyanamid | Process for the preparation of acellular Bordetalla pertussis vaccine |
| US5032398A (en) * | 1986-08-01 | 1991-07-16 | Kaslow Harvey R | Selective modification of the catalytic subunit of pertussis toxin |
| US5165927A (en) * | 1986-08-01 | 1992-11-24 | University Of Southern California | Composition with modified pertussis toxin |
| US5139776A (en) * | 1987-04-24 | 1992-08-18 | The Research Foundation For Microbial Diseases Of Osaka University | Method for culturing Bordetella pertussis, a pertussis toxoid and a pertussis vaccine |
| CA1337859C (en) * | 1987-04-24 | 1996-01-02 | Masashi Chazono | Method for culturing bordetella pertussis, a pertussis toxoid and a pertussis vaccine |
| US5101019A (en) * | 1987-05-22 | 1992-03-31 | Takeda Chemical Industries, Ltd. | Method for removing pertussis endotoxin, a pertussis toxoid and its production |
| JPS6485926A (en) * | 1987-06-24 | 1989-03-30 | Teijin Ltd | Mutant of bordetella pertussis |
| GB8807860D0 (en) * | 1988-04-05 | 1988-05-05 | Connaught Lab | Pertussis vaccine |
| JP2706792B2 (ja) * | 1988-11-29 | 1998-01-28 | 財団法人化学及血清療法研究所 | 百日咳毒素のトキソイド化法 |
| DK0396964T3 (da) * | 1989-04-28 | 1995-10-30 | Sclavo Spa | Pertussistoxin-mutanter, Bordetella-stammer, der er i stand til at producere sådanne mutanter, samt deres anvendelse til udvikling af antipertussis-vacciner |
| GB8910570D0 (en) | 1989-05-08 | 1989-06-21 | Wellcome Found | Acellular vaccine |
| ATE129159T1 (de) * | 1990-02-12 | 1995-11-15 | Smithkline Beecham Biolog | Impfstoff. |
| US5578308A (en) * | 1990-02-12 | 1996-11-26 | Capiau; Carine | Glutaraldehyde and formalin detoxified bordetella toxin vaccine |
| JPH0432188U (en]) * | 1990-07-10 | 1992-03-16 | ||
| EP0669971B1 (en) * | 1991-11-15 | 2003-03-19 | Pfizer Inc. | Method of producing gram-negative bacterial vaccines |
| JP2634545B2 (ja) * | 1992-10-27 | 1997-07-30 | 日本全薬工業株式会社 | Ｒｔｘトキシンファミリーに属する細菌毒素ワクチンの製造法 |
| CN1147259A (zh) * | 1994-04-28 | 1997-04-09 | 武田药品工业株式会社 | 分离百日咳杆菌保护性组分的方法 |
| RU2227746C1 (ru) * | 2003-02-13 | 2004-04-27 | Научно-исследовательский институт вакцин и сывороток им. И.И. Мечникова РАМН | Способ получения анатоксина bordetella pertussis |
| BRPI0402630B8 (pt) * | 2004-07-05 | 2021-05-25 | Fund Butantan | processo de obtenção de vacina pertussis celular menos reatogênica |
| RU2285540C2 (ru) * | 2005-01-20 | 2006-10-20 | Научно-исследовательский институт вакцин и сывороток им. И.И. Мечникова | СПОСОБ ПОЛУЧЕНИЯ АНАТОКСИНА Bordetella pertussis |
| RU2332231C2 (ru) * | 2006-07-31 | 2008-08-27 | Федеральное государственное унитарное предприятие "Научно-производственное объединение по медицинским иммунобиологическим препаратам "Микроген" Министерства здравоохранения Российской Федерации | Способ получения бесклеточной вакцины для иммунопрофилактики коклюша |
| RU2504399C1 (ru) * | 2012-12-06 | 2014-01-20 | Федеральное государственное унитарное предприятие "Научно-производственное объединение по медицинским и иммунопрофилактическим препаратам "Микроген" Министерства здравоохранения Российской Федерации (ФГУП "НПО "Микроген" Минздрава России) | Способ получения бесклеточной вакцины для иммунопрофилактики коклюша |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB512196A (en) * | 1937-08-19 | 1939-08-30 | Lederle Lab Inc | Method of preparing pertussis toxin and toxoid |
| US2359388A (en) * | 1941-02-13 | 1944-10-03 | Lederle Lab Inc | Method of preparing pertussis toxin and toxoid |
| US3135662A (en) * | 1961-01-05 | 1964-06-02 | Burroughs Wellcome Co | Diphtheria toxoid preparation and its production |
| NL6600706A (en]) * | 1965-02-05 | 1966-08-08 | ||
| US4075321A (en) * | 1973-05-04 | 1978-02-21 | Agence Nationale De Valorisation De La Recherche (Anvar) | Vaccines, the process for preparing the same and the applications thereof |
| DE2448530C3 (de) * | 1974-10-11 | 1980-03-27 | Behringwerke Ag, 3550 Marburg | Verfahren zum Herstellen von Derivaten des Diphtherietoxins und diese enthaltende Mittel |
| DE2457047C3 (de) * | 1974-12-03 | 1979-10-31 | Behringwerke Ag, 3550 Marburg | Verfahren zur Herstellung eines Derivates der leichten Kette des Tetanustoxins, dessen Verwendung zur Tetanusprophylaxe |
| FR2393065A1 (fr) * | 1977-05-31 | 1978-12-29 | Merieux Inst | Procede de separation de lipides d'endotoxines bacteriennes et notamment d'endotoxine de bordetella pertussis |
-
1980
- 1980-09-12 JP JP55127825A patent/JPS5750925A/ja active Granted
- 1980-12-30 DE DE8080108246T patent/DE3069433D1/de not_active Expired
- 1980-12-30 EP EP80108246A patent/EP0047802B1/en not_active Expired
-
1981
- 1981-01-05 NO NO810014A patent/NO159667C/no not_active IP Right Cessation
- 1981-01-08 CA CA000368112A patent/CA1152001A/en not_active Expired
- 1981-01-09 DK DK009281A patent/DK155915C/da not_active IP Right Cessation
- 1981-01-23 KR KR1019810000199A patent/KR840001512B1/ko not_active Expired
- 1981-01-23 SU SU813235495A patent/SU1297712A3/ru active
- 1981-01-26 HU HU81164A patent/HU185404B/hu unknown
- 1981-02-04 ES ES499112A patent/ES8202058A1/es not_active Expired
- 1981-09-10 GB GB8127421A patent/GB2083358A/en not_active Withdrawn
-
1982
- 1982-08-16 US US06/408,563 patent/US4455297A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| NO159667B (no) | 1988-10-17 |
| NO810014L (no) | 1982-03-15 |
| EP0047802A2 (en) | 1982-03-24 |
| JPS64928B2 (en]) | 1989-01-10 |
| EP0047802B1 (en) | 1984-10-10 |
| KR830004851A (ko) | 1983-07-20 |
| SU1297712A3 (ru) | 1987-03-15 |
| DE3069433D1 (en) | 1984-11-15 |
| GB2083358A (en) | 1982-03-24 |
| JPS5750925A (en) | 1982-03-25 |
| DK9281A (da) | 1982-03-13 |
| DK155915B (da) | 1989-06-05 |
| EP0047802A3 (en) | 1982-12-29 |
| US4455297A (en) | 1984-06-19 |
| ES499112A0 (es) | 1982-02-01 |
| ES8202058A1 (es) | 1982-02-01 |
| HU185404B (en) | 1985-02-28 |
| DK155915C (da) | 1989-10-23 |
| KR840001512B1 (ko) | 1984-09-29 |
| NO159667C (no) | 1989-02-01 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CA1152001A (en) | Method for producing pertussis toxoid | |
| EP0120532B1 (en) | Mucoid exopolysaccharide vaccine against pseudomonas aeruginosa | |
| US4726947A (en) | Bacterial cell extract, process for preparing same, antitumor preparation containing same, and adjuvant preparation containing same | |
| US4687738A (en) | Method for the production of HA fraction containing protective antigens of Bordetella pertussis and pertussis vaccine | |
| EP0041897B1 (en) | Polysaccharide antigen from streptococcus and vaccines | |
| US4784589A (en) | Purification of pertussis antigens | |
| US4207414A (en) | Polysaccharide antigens | |
| EP0291968B1 (en) | A method for removing pertussis endotoxin, a pertussis toxoid and its production | |
| US4367223A (en) | Vaccine against Group B streptococci | |
| KR940004541B1 (ko) | 트레포네마 히오디센테리아 박테린의 제조방법 | |
| US3438865A (en) | Preparation of bacterial lipopolysaccharides | |
| RU2148412C1 (ru) | Способ получения протективного коклюшного антигена | |
| KR810001317B1 (ko) | 혼합백신의 제조방법 | |
| SU1750690A1 (ru) | Способ получени конъюгированного энтеротоксина ЕSснеRIснIа coLI | |
| KR870001194B1 (ko) | 정제 백일해 예방약의 제조방법 | |
| JPS6324977B2 (en]) | ||
| WO1988000058A1 (fr) | Procede pour la preparation de fractions antigeniques exocellulaires de bordetella pertussis et vaccin contre la coqueluche contenant de telles fractions | |
| Sorensen | An investigation of the antigenic structure of the yeast phase of Histoplasma capsulatum |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MKEX | Expiry |